2-[(3S)-5-Oxooxolan-3-yl]isoindoline-1,3-dione
نویسندگان
چکیده
The oxolan-2-one ring in the title compound, C(12)H(9)NO(4), has an envelope conformation with the atom linking the two five-membered rings being the flap atom.
منابع مشابه
A Green and Efficient One-pot Synthesis of Propanamides by a Three-component Reaction of 2-(2-oxopropyl) isoindoline-1,3-dione, Alkyl isocyanide and an E-cinnamic acid under Catalyst-free Conditions in Water
A green and convenient protocol is described for the preparation of E-1-(alkylamino)-3- (1,3-dioxoisoindolin-2-yl)-2-methyl-1-oxopropan-2-yl viaone-pot three-component reaction between 2-(2-oxopropyl)isoindoline-1,3-dione, an alkyl isocyanide and an E-cinnamic acid in water at room temperature. The methods used to follow the reactions are TLC and NMR, which indicated that there is no side produ...
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A green and convenient protocol is described for the preparation of 1-(alkylamino)-3-(1,3-dioxoisoindolin-2-yl)-2-methyl-1-oxopropan-2-yl benzoates via one-pot three-component reaction between 2-(2-oxopropyl)isoindoline-1,3-dione, an alkyl isocyanide and an aromatic carboxylic acid in water at room temperature. The methods used to follow the reactions are TLC and NMR, which indicated that there...
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Sixteen new phthalimide derivatives were synthesized and evaluated for their in vitro anti-microbial, anti-oxidant and anti-inflammatory activities. The cytotoxicity for all synthesized compounds was also determined in cancer cell lines and in normal human cells. None of the target derivatives had any cytotoxic activity. (ZE)-2-[4-(1-Hydrazono-ethyl) phenyl]isoindoline-1,3-dione (12) showed rem...
متن کامل2-(2,5-Dioxotetrahydrofuran-3-yl)isoindoline-1,3-dione
In the title compound, C(12)H(7)NO(5), the dihedral angle between the isoindole-1,3-dione plane and the least-squares plane of the furan ring is 89.2 (2)°. In the crystal structure, mol-ecules are linked through inter-molecular C-H⋯O hydrogen bonds, forming centrosymmetric dimers.
متن کامل2-(2-Oxothiolan-3-yl)isoindoline-1,3-dione
In the title compound, C(12)H(9)NO(3)S, the isoindoline-1,3-dione group is almost planar, with an r.m.s. deviation of 0.020 Å, whereas the heterocyclic ring approximates to an envelope with the methyl-ene group not adjacent to the S atom in the flap position. A short intra-molecular C-H⋯O contact generates an S(6) ring motif. In the crystal structure, weak aromatic π-π stacking inter-actions oc...
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عنوان ژورنال:
دوره 68 شماره
صفحات -
تاریخ انتشار 2012